Juni
THE ROLE OF TELOMERASE IN CELULLAR SENESCENCE AND ITS IMPLICATIONS FOR ANTI-AGING THERAPY
Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors. One of the primary mechanisms contributing to aging is telomere shortening, which plays a crucial role in genome stability and cellular regeneration. As individuals age, progressive telomere shortening can trigger cellular apoptosis and tissue dysfunction, impacting health and skin aesthetics.
Consequently, telomere-based anti-aging therapies have become a significant focus of strategies aimed at slowing the aging process and improving quality of life. Several studies have explored various therapeutic approaches, including telomerase activation, bioactive compounds, and genetic engineering technologies to maintain telomere length and enhance cellular function. This literature review aims to analyze recent developments in telomere-based anti-aging therapies, evaluate their effectiveness, and discuss their potential applications in health and aesthetic medicine. A deeper understanding of telomere mechanisms and their therapies is expected to facilitate the development of more effective and sustainable anti-aging strategies. The writers are Ratna Shintia Defi, Henrita Ernestia, Ferdinandus Krisna Pukan
Oktober
Susceptibility of Gastroesophageal Reflux Disease Symptoms in Medical Students: A Formative Study
Gastroesophageal Reflux Disease (GERD) is a common chronic condition that can significantly reduce quality of life and result in high morbidity. Medical students, who often experience high levels of pressure during their training, may be especially susceptible to this condition. Various factors, such as lifestyle choices, eating habits, medication, and mental stress, can contribute to the onset of GERD.
Dr. Eviana B. Sutanato and her team conducted a study to explore the relationship between risk factors and the development of GERD among medical students. The study found that the prevalence of GERD among these students is relatively high and identified a significant link between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the occurrence of GERD.
Readers can view the complete report of this study at: https://doi.org/10.36452/jkdoktmeditek.v31i5.3758.
November
Dienogest Therapy Against the Combined Oral Contraceptive Pill in Deep Infiltrating Endometriosis Cases: A Systematic Review and Meta-Analysis
Deep endometriosis is a chronic condition where women experience significant pain, including symptoms such as dysmenorrhea (painful menstruation), chronic pelvic pain, and dyspareunia (pain during intercourse). While medical treatment can relieve symptoms for 50% to 80% of women, about 20% continue to experience pain despite having undergone laparoscopic surgery. For patients seeking pregnancy, optimal management following endometriosis surgery is essential. Although laparoscopic surgery using three-dimensional (3D) laparoscopy technology offers advantages in depth perception, precision, and reduced surgical strain compared to traditional two-dimensional (2D) laparoscopy, previous studies have not shown significant differences in outcomes. Therefore, Indra Adi Susianto and his team conducted a systematic review to evaluate the latest evidence comparing the effects of dienogest and combined oral contraceptive pills (COCP) on pain scores related to dysmenorrhea, dyspareunia, and dyschezia in patients with deep endometriosis. Their article was published in “Gynecology and Minimally Invasive Therapy.” Readers can access the full paper for more details.
Article Type: Review
Prinsip-Prinsip Riset Implementasi
Kebutuhan dan minat terhadap riset implementasi terus meningkat, terutama dalam bidang kesehatan. Namun, referensi untuk pembelajaran secara sistematis dari praktik riset implementasi dalam sistem kesehatan dan ranah teknis pelayanan kesehatan masih terbatas. Oleh karena itu, buku berjudul Prinsip-Prinsip Riset Implementasi ditulis untuk menjawabi kebutuhan tersebut.
Buku ini mengulas prinsip-prinsip riset implementasi, khususnya dalam bidang kesehatan. Dua belas bab dalam buku ini mengemas konsep dan prinsip dasar; pertimbangan strategi implementasi; teori, model, kerangka kerja; metode-desain; strategi diseminasi; dan pengembangan keterampilan untuk melakukan riset implementasi. Buku ini menawarkan perspektif lengkap dari tujuan penggunaan riset implementasi. Mulai dari penggunaan riset implementasi untuk meningkatkan kesehatan masyarakat, menyediakan informasi atau bukti untuk perumusan dan implementasi kebijakan atau intervensi lainnya, memperkuat pemberian layanan kesehatan, hingga memberdayakan masyarakat atau mitra dan penerima manfaat. Salah satu tim penulis buku ini adalah Perigrinus H Sebong, pengajar sekaligus peneliti di FK-SCU
Buku Karya: Kategori Kedokteran Umum
Desember
Effect of mesenchymal stem cells on reducing melanin levels in response to UV radiation in male C57BL/6 mice
Melanin is a pigment produced by melanocytes through a process called melanogenesis, which involves polymerization and oxidation. This pigment is found in the skin, hair, and eyes, serving as a natural protective mechanism. However, melanin levels can increase in response to damage, particularly from ultraviolet (UV) radiation, which triggers melanogenesis. This leads to an excess production of melanin and elevated levels of reactive oxygen species (ROS), potentially resulting in hyperpigmentation.
To address this issue, our researcher, Aprilia Karen Mandagie, and her team, from the Faculty of Medicine at Soegijapranata Catholic University, are conducting laboratory-based research. Their study explores the potential of mesenchymal stem cells (MSCs) as an alternative approach to prevent UV-induced skin hypermelanosis in male C57BL/6 mice.
Article Type: Laboratory-based study